role of 5-hydroxytryptamine 1a receptors in 6-hydroxydopmaine-induced catalepsy-like immobilization in rats: a therapeutic approach for treating catalepsy of parkinson’s disease
نویسندگان
چکیده
we have shown that buspirone, a partial agonist of 5-hydroxytryptamine 1a (5-ht1a) receptors, improves motor dysfunctions induced by 6-hydroxydopamine (6-ohda) and haloperidol in rats. the present work extends these findings by investigating the role of 5-ht1a receptors on catalepsy-like immobilization in rats, a model of parkinson’s disease. catalepsy was induced by unilateral infusion of 6-oh-dopamine (8 µg/2µl/rat) into the central region of the substantia nigra, compact part (snc) and assayed by bar-test method 5, 60, 120 and 180 min after the drugs administration. the involvement of 5-ht1a receptors in 6-ohda-induced catalepsy was studied through intraperitoneal (0.25, 0.5 and 1mg/kg ip) and intrasubstantia nigra, compact part (10 µg/rat, intra-snc) injection of 8-hydroxy-2-[di-n-propylamino] tetralin (8-ohdpat) as well as administration of 1-(2-methoxyphenyl)-4-[4-(2-pthalimmido) butyl] piperazine hydrobromide (0.1, 0.5 and 1 mg/kg, nan-190, ip). nan-190 (1 mg/kg, ip) and 8-ohdpat (1 mg/kg, ip and 10 µg/rat, intra-snc) increased and decreased 6-ohda-induced catalepsy respectively. in normal (non 6-ohda-lesioned) rats, nan-190 (1 mg/kg, ip) increased the elapsed time in bar-test while 8-ohdpat did not produce any significant effect. the anticataleptic effect of 8-ohdpat (1 mg/kg, ip) was reversed markedly by co-injection with nan-190 (1 mg/kg, ip). these findings suggest that 5-ht1a receptors are involved in 6-ohda-induced catalepsy-like immobilization.
منابع مشابه
Role of 5-Hydroxytryptamine 1A Receptors in 6-Hydroxydopmaine-induced Catalepsy-like Immobilization in Rats: a Therapeutic Approach for Treating Catalepsy of Parkinson’s Disease
We have shown that buspirone, a partial agonist of 5-hydroxytryptamine 1A (5-HT1A) receptors, improves motor dysfunctions induced by 6-hydroxydopamine (6-OHDA) and haloperidol in rats. The present work extends these findings by investigating the role of 5-HT1A receptors on catalepsy-like immobilization in rats, a model of Parkinson’s disease. Catalepsy was induced by unilateral infusion of 6-OH...
متن کاملRole of 5-Hydroxytryptamine 1A Receptors in 6-Hydroxydopmaine-induced Catalepsy-like Immobilization in Rats: a Therapeutic Approach for Treating Catalepsy of Parkinson’s Disease
We have shown that buspirone, a partial agonist of 5-hydroxytryptamine 1A (5-HT1A) receptors, improves motor dysfunctions induced by 6-hydroxydopamine (6-OHDA) and haloperidol in rats. The present work extends these findings by investigating the role of 5-HT1A receptors on catalepsy-like immobilization in rats, a model of Parkinson’s disease. Catalepsy was induced by unilateral infusion of 6-OH...
متن کاملRole of 5-Hydroxytryptamine 1A Receptors in 6-Hydroxydopmaine-induced Catalepsy-like Immobilization in Rats: a Therapeutic Approach for Treating Catalepsy of Parkinson’s Disease
We have shown that buspirone, a partial agonist of 5-hydroxytryptamine 1A (5-HT1A) receptors, improves motor dysfunctions induced by 6-hydroxydopamine (6-OHDA) and haloperidol in rats. The present work extends these findings by investigating the role of 5-HT1A receptors on catalepsy-like immobilization in rats, a model of Parkinson's disease. Catalepsy was induced by unilateral infusion of 6-OH...
متن کاملBuspirone improves 6-hydroxydopamine-induced catalepsy through stimulation of nigral 5-HT(1A) receptors in rats.
Receptors for 5-HT(1A) are widely distributed throughout the basal ganglia, and their activation results in an inhibition of dopamine (DA) release. This study aimed to investigate the effect of buspirone, as a partial agonist of 5-HT(1A) receptors, on 6-hydroxydopamine (6-OHDA)-induced catalepsy in male Wistar rats. Catalepsy was induced by unilateral infusion of 6-OH-DA (6 microg/2 microl/rat)...
متن کاملEffect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats
Objective(s): Neuroinflammation and oxidative stress play a key role in pathogenesis of Parkinson’s disease (PD). In the present study we investigated the effect of reactive oxygen species (ROS) scavenger WR-1065 on catalepsy and cerebrospinal fluid (CSF) level of interleukin 6(IL-6) and striatum superoxide dismutase (SOD) activity in 6-hydroxydopamine (6-OHDA) induced experimental model of PD...
متن کاملDose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors.
PURPOSE Progressive loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) leads to impairment of motor skills. Several evidences show that the role of serotonergic system in regulation of normal movement is pivotal and mediates via 5-HT1A receptors. Our previous study has shown that fluoxetine in acute injections able to attenuate catalepsy in 6-hy...
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عنوان ژورنال:
the iranian journal of pharmaceutical researchجلد ۱۱، شماره ۴، صفحات ۱۱۷۵-۱۱۸۱
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